About Me
Computational Biologist located at the Cambridge Centre for Proteomics (CCP), University of Cambridge, UK. My main area of research focuses on computational analysis of high-throughput quantitative spatial proteomics data and development of new machine learning tools and R packages.
Projects
The bandle package: bandle is an R package for the Bayesian analysis of differential subcellular localisation experiments.
The pRoloc package: pRoloc implements machine learning and visualisation methods for the analysis and interogation of quantitiative mass spectrometry data to reliably infer protein sub-cellular localisation.
The pRolocGUI package: pRolocGUI comprises functions to interactively visualise organelle (spatial) proteomics data on the basis of pRoloc, pRolocdata and shiny.
The pRolocdata package: pRolocdata is a data package containing mass-spectrometry based spatial proteomics data sets and protein complex separation data.
Experience
University of Cambridge
Computational Biologist
November 2010 - Present
https://proteomics.bio.cam.ac.uk
I am a Postdoctoral Research Associate in Professor Kathryn Lilley group located in Cambridge Centre for Proteomics at the University of Cambridge. My research focuses on R package development and the computational analysis of high-throughput quantitative spatial proteomics data. This includes the application and development of new machine learning tools. Our work is contributed to the R Bioconductor project in the form of dedicated software packages (see projects) pioneered by Prof Laurent Gatto at UCLouvain, Belgium.
University of Cambridge
Undergraduate Mathematics Supervisor
November 2010 - July 2011
Elementary Mathematics supervisor for Wolfson College and Newnham College at the University of Cambridge.
GlaxoSmithKline (GSK)
Industrial CASE Student
October 2006 - May 2010
CASE (Collaborative Awards in Science and Engineering) PhD studentship with GSK (Harlow, UK) working in the Computational Chemistry Division in R&D, under the supervision of Dr Ian Wall and Dr Frank Blaney. My main research focused on using molecular modelling and molecular dynamics simulation techniques to gain an insight into the structural and functional properties of GPCRs in their multiple states.
Education
University of Essex
PhD Computational Chemistry/Biology
2006 - 2010
Funded BBSRC CASE (Collaborative Awards in Science and Engineering) Award project under the supervision of Prof. Chris Reynolds (Dept. of Biological Sciences, University of Essex) and Dr. Ian Wall (GSK, Harlow). My main research focused on structure-based drug-design in which I used molecular modelling and molecular dynamics simulation techniques to gain an insight into the structural and functional properties of GPCRs in their multiple states.
University of Essex
BSc (Hons) Mathematics (1st Class)
2003-2006